PMC

Survival curves for salt sensitive and salt resistant subjects. Kaplan-Meier survival curves for normotensive salt-resistant subjects (N+R), normotensive salt-sensitive subjects (N+S), hypertensive salt-resistant subjects (H+R), and hypertensive salt-sensitive subjects (N+S) over the follow-up period. As noted, only the N+R group had an increased survival. Adapted from Weinberger et al.

Flow diagram detailing the role of kallikrein in promoting diuresis. Kallikrein secretion, triggered by excess sodium in the connecting tubule, generates renal kinins which act on the brady-kinin receptor 2 (BK B2 R) to promote diuresis.