PMC

Flow diagram for subject enrollment. Of 2,011 transplants performed at the participating centers, 1,255 were enrolled in the Lung Transplant Outcomes Group cohort. “Not consented” refers to patients who were transplanted before being approached for consent. “Consented but not enrolled due to logistics” includes patients who were unable to give a blood sample as part of the study.

Standardized incidence of grade 3 primary graft dysfunction (PGD) across the 10 centers. Standardized risk of grade 3 PGD represents the postestimation marginalized standardized risks for grade 3 PGD and was calculated based on the final logistic regression model. Dots are the point estimates and error bars represent the 95% confidence intervals.

Standardized grade 3 primary graft dysfunction (PGD) risk for donor, recipient, and perioperative variables. Standardized risk of grade 3 PGD represents the postestimation marginalized standardized risks for grade 3 PGD and was calculated based on the final logistic regression model. Dots represent the point estimate for adjusted standardized risk from a logistic regression equation containing donor smoking, reperfusion Fi_O2, total ischemic time, recipient sex and parity, World Health Organization categorized severity of pulmonary hypertension, volume of packed red blood cell (PRBC) transfusion, recipient body mass index (BMI), use of cardiopulmonary bypass, transplant type, center, and preoperative diagnosis, with the bar representing 95% confidence intervals. Standardized risks represent the estimated risk of grade 3 PGD if all variables were kept stable except for altering the variable of interest; for example, the estimated grade 3 PGD risk if all of the patients alternatively received or did not receive cardiopulmonary bypass.