PMC

Histologic findings in heart, kidney and lung tissues following Endostar administration (H&E staining, ×200). (A–C) Tissues of (A) heart, (B) kidney and (C) lung in the saline group. (D–F) Tissues of (D) heart, (E) kidney and (F) lung in the intermittent administration group. (G–I) Tissues of (G) heart, (H) kidney and (I) lung in the continuous administration group. H&E, hematoxylin and eosin.

CD146-labeled microvessels in heart, kidney and lung tissues following Endostar administration (x200). (A–C) CD146-labeled microvessels in the tissues of (A) heart, (B) kidney and (C) lung in the saline group. (D–F) CD146-labeled microvessels in the tissues of (D) heart, (E) kidney and (F) lung in the intermittent administration group. (G–I) CD146-labeled microvessels in the tissues of (G) heart, (H) kidney and (I) lung in the continuous administration group.

Flow cytometric analysis of CD11b⁻CD146⁺CD105⁺ cells in the peripheral blood nucleated cell population in (A) the control group, (B) saline group, (C) intermittent administration group and (D) continuous administration group. FITC:CD11b, PE:CD146, APC:CD105. FITC, fluorescein isothiocyanate; PE, phycoerythrin; APC, allophycocyanin.