PMC

The effect of HUT/LBNP on plasma levels of F1+2 (panel A) and on TAT (panel B) are shown. Each graph represents a representative experiment.

The effect of HUT/LBNP on hemoconcentration is shown with respect to the relative change of the plasma volume. Data are presented as mean ± SD.

The effect of HUT/LBNP on thrombin Peak (panel A) and on ETP (panel B), both evaluated by means of CAT, and on plasma levels of prothrombin (panel C) and TFPI (panel D), as well as on TF (panel E) and on t-PA (panel F) are shown. Each graph represents a representative experiment.

Control blood was taken after 30 min supine rest (sample 1). The orthostatic stimulation phase started with passive 70° head-up for 4 min, then 15 mm Hg LBNP was commenced in this position and increased by 15 mm Hg every 4 min. After application of −45 mm Hg suction or after development of dizziness, LBNP was stopped and the table tilted back. Supine position was maintained for 20 min, at the end of which the last blood sample was taken (sampling point 11).