PMC

Change of food consumption (A) and body weight gain (B) in LETO and OLETF rats. In LETO rats, the average consumption of the control group was 27±1 g per day while the average consumption of the fenofibrate group was 24±1 g per day (p<0.05). Values are means±SEM. n=5.

Effects of fenofibrate on the expression of PPARα and CCK in the small intestines of LETO and OLETF rats. (A) Relative amounts of PPARα and CCK mRNA were analyzed by RT-PCR in the small intestine of LETO rats. Values shown (means±SEM) are normalized against GAPDH mRNA. n=5. ^*p<0.05 vs. control. (B) Protein levels of PPARα and CCK were analyzed by western blotting.

Effects of fenofibrate on the expression of PPARα and CCK in Caco-2 cells. (A) The expression of CCK increased dose-dependently with a low-dose treatment of fenofibrate (3, 10 and 30 µM) for 24 h. (B) The expression of CCK in Caco-2 cells was induced by several kinds of PPARα agonists; fenofibrate 100 µM (feno), bezafibrate 100 µM (beza) and clofibrate 250 µM (clo). Experiments shown were repeated three times to confirm reproducibility.