PMC

ORs and 95% CIs of each of the novel genetic association with SSc found in this study, in either the meta-analysis of all cohorts and each population separately.

Schematic showing the overall process followed during the present study, along with the number of SNPs associated and considered in each step. lcSSc, limited cutaneous scleroderma; dcSSc, diffuse cutaneous scleroderma; ACA, anti-centromere autoantibody; ATA, anti-topoisomerase autoantibody.

The Manhattan plot of the GWAS and replication cohorts meta-analysis. Grey dots represent P-values of SNPs which are genotyped only in the GWAS cohorts in the previous study by Radstake et al. (). Other color dots represent P_MH values of the 720 SNPs which were in both the GWAS and the replication cohorts (Mantel–Haenszel meta-analysis). Gene names in black have been previously reported as genetic risk factors for SSc, while gene names in red are novel ones.