PMC

Peripheral clearance of Aβ. In the brain, Aβ can oligomerize to form higher-order structures, including protofibrils and fibrils. LRP1 shuttles monomeric Aβ across the BBB and into the blood; RAGE is responsible for Aβ influx. sLRP1 and hepatic LRP1 assist in Aβ degradation via several Aβ-degrading enzymes, including NEP, insulin degrading enzyme (IDE), angiotensin converting enzyme (ACE), and plasmin. Sehgal et al. () find that WS extract reverses AD pathology by up-regulating sLRP1 and hepatic LRP1, thereby shifting the equilibrium to reduce the total Aβ load and oligomerization.