PMC

Regional [¹¹C]-(+)-PHNO BP_ND in MA users (n = 16; gray circles) and in control subjects (n = 16; white circles). *p < 0.05, corrected; ^#p < 0.1, corrected.

A, Voxel-wise group comparison illustrating higher [¹¹C]-(+)-PHNO BP_ND in the midbrain of MA-abusing than control subjects (t_max = 2.79; p = 0.01; MNI coordinates: 8, −10, −12) and cluster above the p < 0.05 significance threshold when using the random field FWE correction for multiple comparisons within a small volume (10-mm-radius sphere; MNI coordinates: 10, −18, −12). B, Voxel-wise group comparison illustrating lower [¹¹C]-(+)-PHNO BP_ND in the striatum of MA-abusing than control subjects (t_max = 3.90; p = 0.04, uncorrected; k_E = 21; MNI coordinates: 24, 2, 0). The image is thresholded at a probability uncorrected for multiple comparisons.