PMC

Pain modulation as a function of level of sustained sedentary time in FM patients. Pain modulation reflects the difference in pain intensity and unpleasantness ratings between the pain alone run and the combined pain and cognitive task runs.
PA = Pain alone, CS = Congruent Stroop plus pain, IS = Incongruent Stroop plus pain

Pain modulation as a function of level of low-moderate physical activity in FM patients. Pain modulation reflects the difference in pain intensity and unpleasantness ratings between the pain alone run and the combined pain and cognitive task runs.
PA = Pain alone, CS = Congruent Stroop plus pain, IS = Incongruent Stroop plus pain

Brain regions showing significant associations between accelerometer measures of low-moderate physical activity and brain responses during pain modulation (incongruent Stroop task), controlling for FIQ scores. Significant positive correlations were found between accelerometer measures of low-moderate physical activity and brain activity in the R DLPFC (1) and the PAG (2). Images are shown with a voxelwise threshold set at P = 0.005. For the DLPFC, cluster-size thresholding was set at 200 mm³ and for the PAG cluster-size thresholding was set at 40 mm³. Functional timeseries data (percent signal change) were extracted and are shown plotted against average minutes of low-moderate physical activity per day with the corresponding R² value. Percent signal change data values are based on the subtraction of the BOLD responses during both the pain-alone and Stroop-alone runs from the combined pain-during-Stroop runs.

Brain regions showing significant associations between accelerometer measures of sustained sedentary time and brain responses during pain modulation (congruent Stroop task), controlling for FIQ and BID scores. Negative correlations were found in the bilateral DLPFC (1 and 6), thalamus (2), right pre and postcentral gyri (3, 4) and right superior frontal gyrus (5); left pre and postcentral gyri are not pictured. Images are shown with a voxelwise threshold set at P = 0.005 and cluster-size thresholding at 200 mm³. Functional timeseries data (percent signal change) for each individual were extracted and are shown plotted against minutes of sustained sedentary time per week with the corresponding R² values. Percent signal change data values are based on the subtraction of the BOLD responses during both the pain-alone and Stroop-alone runs from the combined pain-during-Stroop runs.

Brain regions showing significant associations between accelerometer measures of low-moderate physical activity and brain responses during pain modulation (congruent Stroop task), controlling for FIQ scores. A significant negative correlation was found in the left anterior insula (1) and a significant positive correlation was founding in the dorsal regions of the posterior cingulate cortex (2). Images are shown with a voxelwise threshold set at P = 0.005 and cluster-size thresholding at 200 mm³. Functional timeseries data (percent signal change) for each individual were extracted and are shown plotted against average minutes of low-moderate physical activity per day with the corresponding R² values. Percent signal change data values are based on the subtraction of the BOLD responses during both the pain-alone and Stroop-alone runs from the combined pain-during-Stroop runs.