PMC

See caption to for explanation.

The abscissa shows total numbers of brain cysts, the ordinate shows antibody titers determined by the complement fixation test.

The abscissa shows body weight, the ordinate shows time (in days) after inoculation. Error bars denote the 95% confidence interval.

(A) A pair of cysts (arrows) in the molecular layer of the cerebellar cortex. Arrowheads point to the Purkinje cells. GrL, granular layer; fis, cerebellar fissure; MoL, molecular layer. (B–C) A single cyst (B) and a cyst triad (C) in the isocortex. Scales, 100 µm (in C for B, C).

(A–E) Perivascular and leptomeningeal infiltrations of inflammatory cells. (A, B) Detail of perivascular cuffing. (C–E) Leptomeningeal and perivascular cuffing on the surface of cerebral cortex (C), in the interhemispheric region (D) and in the cerebellum (E). (F) Extensive necrosis in the hypothalamus (observed in one mouse). (G) Vacuolisation of brain parenchyma in the thalamus. Note that vessels were dilated post mortem by pressure of the perfusion liquids. Scales, 100 µm (A), 200 µm (B, C, G, in G for D–G).

Coronal diagrams compile results from five infected CD1 mice. Tissue cyst locations are indicated by color circles (each circle represents a single cyst); colors refer to the individual animals investigated. The cyst density within brain regions is classified into five classes – very high, high, medium, low, and very low, which are colored red, pink, white, blue, and dark blue, respectively. Grey indicates the dopaminergic system. The antero-posterior positions of the sections are determined by Bregma coordinates. See for abbreviations.