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Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

Chuan Hu, Yujun Song, Yiwei Zhang, Siqin He, Xueying Liu, Xiaotong Yang, Tao Gong, Yuan Huang, Huile Gao

Acta Pharm Sin B. 2023 May; 13(5): 2176–2187. Published online 2023 Feb 21. doi: 10.1016/j.apsb.2023.02.009

PMCID:: PMC10213972

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Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression

Chuanfeng Tang, Qiaona Wang, Jingyan Shen, Congying Wang, Hong Ding, Shiyu Wen, Fan Yang, Ruiqing Jiao, Xingxin Wu, Jianmei Li, Lingdong Kong

Acta Pharm Sin B. 2023 May; 13(5): 2017–2038. Published online 2023 Mar 15. doi: 10.1016/j.apsb.2023.03.010

PMCID:: PMC10213873

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The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses

Kan Xing Wu, Thinesshwary Yogarajah, Marcus Wing Choy Loe, Parveen Kaur, Regina Ching Hua Lee, Chee Keng Mok, Yi Hao Wong, Patchara Phuektes, Li Sze Yeo, Vincent T.K. Chow, Yong Wah Tan, Justin Jang Hann Chu

Acta Pharm Sin B. 2023 May; 13(5): 2039–2055. Published online 2023 Mar 18. doi: 10.1016/j.apsb.2023.03.015

PMCID:: PMC10213844

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Cellular nanovesicles for therapeutic immunomodulation: A perspective on engineering strategies and new advances

Endong Zhang, Philana Phan, Zongmin Zhao

Acta Pharm Sin B. 2023 May; 13(5): 1789–1827. Published online 2022 Aug 28. doi: 10.1016/j.apsb.2022.08.020

PMCID:: PMC10213819

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The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms

Jie Chen, Xiaohong Wei, Qian Zhang, Yuzhuo Wu, Guiyang Xia, Huan Xia, Lingyan Wang, Hongcai Shang, Sheng Lin

Acta Pharm Sin B. 2023 May; 13(5): 1919–1955. Published online 2023 Feb 11. doi: 10.1016/j.apsb.2023.02.005

PMCID:: PMC10213818

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Genomic, transcriptomic, and epigenomic analysis of a medicinal snake, Bungarus multicinctus, to provides insights into the origin of Elapidae neurotoxins

Jiang Xu, Shuai Guo, Xianmei Yin, Mingqian Li, He Su, Xuejiao Liao, Qiushi Li, Liang Le, Shiyu Chen, Baosheng Liao, Haoyu Hu, Juan Lei, Yingjie Zhu, Xiaohui Qiu, Lu Luo, Jun Chen, Ruiyang Cheng, Zhenzhan Chang, Han Zhang, Nicholas Chieh Wu, Yiming Guo, Dianyun Hou, Jin Pei, Jihai Gao, Yan Hua, Zhihai Huang, Shilin Chen

Acta Pharm Sin B. 2023 May; 13(5): 2234–2249. Published online 2022 Nov 17. doi: 10.1016/j.apsb.2022.11.015

PMCID:: PMC10213816

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Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling

Yun Teng, Yixue Huang, Hao Yu, Cenhao Wu, Qi Yan, Yingjie Wang, Ming Yang, Haifeng Xie, Tianyi Wu, Huilin Yang, Jun Zou

Acta Pharm Sin B. 2023 May; 13(5): 2269–2280. Published online 2023 Feb 28. doi: 10.1016/j.apsb.2023.02.018

PMCID:: PMC10213799

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Entinostat, a class I selective histone deacetylase inhibitor, plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer: A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial

Binghe Xu, Qingyuan Zhang, Xichun Hu, Qing Li, Tao Sun, Wei Li, Quchang Ouyang, Jingfen Wang, Zhongsheng Tong, Min Yan, Huiping Li, Xiaohua Zeng, Changping Shan, Xian Wang, Xi Yan, Jian Zhang, Yue Zhang, Jiani Wang, Liang Zhang, Ying Lin, Jifeng Feng, Qianjun Chen, Jian Huang, Lu Zhang, Lisong Yang, Ying Tian, Hongyan Shang

Acta Pharm Sin B. 2023 May; 13(5): 2250–2258. Published online 2023 Feb 9. doi: 10.1016/j.apsb.2023.02.001

PMCID:: PMC10213795

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Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects

Wei Wei, Qingxuan Zeng, Yan Wang, Xixi Guo, Tianyun Fan, Yinghong Li, Hongbin Deng, Liping Zhao, Xintong Zhang, Yonghua Liu, Yulong Shi, Jingyang Zhu, Xican Ma, Yanxiang Wang, Jiandong Jiang, Danqing Song

Acta Pharm Sin B. 2023 May; 13(5): 2138–2151. Published online 2022 Dec 14. doi: 10.1016/j.apsb.2022.12.009

PMCID:: PMC10213791

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Supramolecular approaches for insulin stabilization without prolonged duration of action

Rolande Meudom, Yanxian Zhang, Michael A. VandenBerg, Lei Zou, Yi Wolf Zhang, Matthew J. Webber, Danny Hung-Chieh Chou

Acta Pharm Sin B. 2023 May; 13(5): 2281–2290. Published online 2023 Jan 12. doi: 10.1016/j.apsb.2023.01.007

PMCID:: PMC10213764

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Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders

Rania Awad, Avi Avital, Alejandro Sosnik

Acta Pharm Sin B. 2023 May; 13(5): 1866–1886. Published online 2022 Jul 9. doi: 10.1016/j.apsb.2022.07.003

PMCID:: PMC10213616

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Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries

Huitong Ruan, Yongfang Li, Cheng Wang, Yixu Jiang, Yulong Han, Yiwei Li, Dandan Zheng, Jing Ye, Gang Chen, Guo-yuan Yang, Lianfu Deng, Ming Guo, Xingcai Zhang, Yaohui Tang, Wenguo Cui

Acta Pharm Sin B. 2023 May; 13(5): 2202–2218. Published online 2022 Jun 10. doi: 10.1016/j.apsb.2022.06.007

PMCID:: PMC10213615

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mRNA delivery in cancer immunotherapy

Yichen Zhong, Shi Du, Yizhou Dong

Acta Pharm Sin B. 2023 Apr; 13(4): 1348–1357. Published online 2023 Mar 5. doi: 10.1016/j.apsb.2023.03.001

PMCID:: PMC10150179

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On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition

Xiaoqing Liu, Shuang Liang, Xiao Sang, Lili Chang, Shunli Fu, Han Yang, Huizhen Yang, Yongjun Liu, Na Zhang

Acta Pharm Sin B. 2023 Apr; 13(4): 1740–1754. Published online 2022 Sep 12. doi: 10.1016/j.apsb.2022.09.004

PMCID:: PMC10150160

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The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation

Yiwei Zhu, Lin Lei, Xinghui Wang, Linfang Chen, Wei Li, Jinxia Li, Chenchen Zhao, Xiliang Du, Yuxiang Song, Wenwen Gao, Guowen Liu, Xinwei Li

Acta Pharm Sin B. 2023 Apr; 13(4): 1616–1630. Published online 2023 Jan 29. doi: 10.1016/j.apsb.2023.01.019

PMCID:: PMC10150139

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Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis

Yau-tuen Chan, Hor-yue Tan, Yuanjun Lu, Cheng Zhang, Chien-shan Cheng, Junyu Wu, Ning Wang, Yibin Feng

Acta Pharm Sin B. 2023 Apr; 13(4): 1554–1567. Published online 2023 Feb 2. doi: 10.1016/j.apsb.2023.01.020

PMCID:: PMC10150138

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Recent progress of aptamer‒drug conjugates in cancer therapy

Jiaxuan He, Qiao Duan, Chunyan Ran, Ting Fu, Yuan Liu, Weihong Tan

Acta Pharm Sin B. 2023 Apr; 13(4): 1358–1370. Published online 2023 Jan 26. doi: 10.1016/j.apsb.2023.01.017

PMCID:: PMC10150127

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Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/PAD4 pathway

Changjun Lv, Minghui Sun, Yilei Guo, Wenxin Xia, Simiao Qiao, Yu Tao, Yulai Fang, Qin Zhang, Yanrong Zhu, Yusufu Yalikun, Yufeng Xia, Zhifeng Wei, Yue Dai

Acta Pharm Sin B. 2023 Apr; 13(4): 1600–1615. Published online 2023 Jan 18. doi: 10.1016/j.apsb.2023.01.016

PMCID:: PMC10150100

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Editorial of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications

Wei Tao

Acta Pharm Sin B. 2023 Apr; 13(4): 1346–1347. Published online 2023 Mar 8. doi: 10.1016/j.apsb.2023.03.005

PMCID:: PMC10150037

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The tumor therapeutic potential of long non-coding RNA delivery and targeting

Shuo Han, Xinru Chen, Leaf Huang

Acta Pharm Sin B. 2023 Apr; 13(4): 1371–1382. Published online 2022 Dec 13. doi: 10.1016/j.apsb.2022.12.005

PMCID:: PMC10149988

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