Association of glucose levels with perceived age. The figure depicts the association between glucose level and perceived age (n = 602). Non-diabetic subjects (n = 569) were divided over tertiles of glucose and diabetic subjects (n = 33) included as a fourth category. Mean perceived age and obtained p values were adjusted for gender, chronological age, body mass index, current smoking, photo-damage score, and Ln (insulin) level as described in “.” For the non-diabetic subjects, the mean perceived age (SE) was 59.6 years (0.3) in the low, 60.2 years (0.3) in the medium, and 60.6 years (0.3) in the high glucose tertile. For the diabetic subjects, the mean perceived age (SE) was 61.2 years (0.6). In a model using only the non-diabetic subjects, we observed a statistical significant positive trend (p trend = 0.009) for the increase in perceived age dependent on glucose tertiles. Inclusion of the diabetic subjects in the model also revealed a highly significant positive trend (p trend = 0.002)