PMC

Cardiovascular outcomes in ATHENA versus AFFIRM, AF-CHF.

Chemical structure of amiodarone and dronedarone (Reproduced with permission).

Death, non-cardiovascular and cardiovascular death rates in ATHENA.
Abbreviation: ACS, acute coronary syndrome.

Cardiovascular hospitalization rates in ATHENA.
Abbreviations: ACS, acute coronary syndrome; CV, cardiovascular; CHF, congestive heart failure.

Effect of dronedarone on stroke endpoints in ATHENA.
Abbreviations: ACS, acute coronary syndrome; CV, cardiovascular; TIA, transient ischemic attack.

Comparative efficacy of antiarrhythmic drugs including dronedarone in maintaining sinus rhythm in placebo-controlled or active-controlled trials. Modified from reference .
Note: *At 6 months; ^†Mean follow-up 7 months.
Abbreviations: CTAF, Canadian Trial of Atrial Fibrillation; SAFE-T, Sotalol Amiodarone Atrial Fibrillation Efficacy Trial; DAFNE, Dronedarone Atrial Fibrillation Study after Electrical Cardioversion; EURIDIS, European Trial in Atrial Fibrillation or Flutter Patients Receiving Dronedarone for the Maintenance of Sinus Rhythm; ADONIS, American-Australian-African Trial with Dronedarone in Atrial Fibrillation or Flutter for the Maintenance of Sinus Rhythm; DIONYSOS, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety of Dronedarone vs. Amiodarone for at least 6 months for the Maintenance of Sinus Rhythm in Patients with AF.