PMC

Comparison of average PiB uptake from four brain regions in the three genotype groups (GG, AG and AA) of rs7551288. ‘A’ represents the minor allele and ‘G’ represents the major allele of this SNP

Overview of steps used for the analyses. a Gene-based association analysis of amyloid-pathway associated candidate genes. b Whole-brain voxel- and cluster-wise analysis. SNP-single nucleotide polymorphism; APOE-apolipoprotein E; APP-amyloid beta (A4) precursor protein; PiB-Pittsburgh Compound B; PET-positron emission tomography; MRI-magnetic resonance imaging; MNI-Montreal Neurological Institute; MP-RAGE-3D magnetization prepared rapid acquisition gradient echo

Visualization of the results of statistical parametric mapping analysis. The regions with significantly (uncorrected p < 0.005, cluster size = 50 voxels) increased PiB uptake in 35 participants with the GG genotype group compared to 50 participants with the AG and 18 participants with the AA genotype groups are shown in color. The red-to-yellow scale indicates increasing statistical significance of differences in PiB uptake