PMC

immunohistochemical detection of AURKA protein in lung cancer. AURKA was predominantly expresses in nuclear compartment of BAC, ADC and SQC (A, B, C, respectively). Original Magnification 200×. ). ADC = Adenocarcinoma, SQC = Squamous cell carcinoma, BAC = Bronchiolo-alveolar carcinoma.

Increased AURKA gene expression in NSCLC patients. Box plot diagram shows the increased expression level of AURKA mRNA in 83 NSCLC respect to the paired non-tumoral tissues.

AURKA expression patterns in NSCLC correlate with tumor subtype and tumor differentiation grade. Box plot diagrams showing the modulations of AURKA mRNA in 83 NSCLC subtypes specimens. A) AURKA was significantly up-modulated in: squamous, adeno and large cells carcinomas (p = 0.029). B) AURKA was significantly up-modulated in moderately and poorly differentiated lung cancers (p < 0.01). Dotted lines correspond to a cut-off of ± 2 fold changes (log₂(FC) ± 1). ADC = Adenocarcinoma, SQC = Squamous cell carcinoma, BAC = Bronchiolo-alveolar carcinoma and LCC = Large cell carcinoma. Values in parentheses indicate the patients' number in each subgroups.