PMC

The relationship between D₂-like receptor availability in the caudate nucleus (black circles), putamen (gray circles), or ventral striatum (open circles) and the probability of making a correct response following positive feedback during the acquisition of stimulus–reward association is shown. The linear relationship between the probability of making a correct response following positive feedback and D₂-like receptor availability in the caudate nucleus is represented by the black line.

The relationship between D₂-like receptor availability in the striatum (caudate nucleus, black circles; putamen, gray circles; and ventral striatum, open circles) and the average number of trials required to reach criterion during the acquisition phase (A), the retention phase (B), and the reversal phase (C). The inverse function best modeled the relationship between reversal learning and D₂-like receptor availability in the caudate nucleus (solid curve) and the putamen (dashed curve).

The relationship between D₂-like receptor in the three striatal regions (caudate nucleus, black circles; putamen, gray circles; and ventral striatum, open circles) and feedback sensitivity during the reversal phase. The probability of making a correct response following positive feedback was related to D₂-like receptor availability in the caudate nucleus (solid curve) and the putamen (dashed curve) (A), while the probability of making a perseverative response following positive feedback was related to D₂-like receptor availability in the caudate nucleus (solid curve) (B). No relationship was detected between the probability of making an incorrect response following negative feedback and D₂-like receptor availability in any of the striatal regions examined (C).

Statistical maps (p values) from the voxelwise regression of D₂-like receptor binding potential on the reversal-learning measures. The relationship between D₂-like receptor availability and the average number of trials required to reach criterion in the last three reversal sessions is presented in blue in A. The relationship between D₂-like receptor availability and the probability of following positive feedback with a perseverative response in the last three reversal sessions is presented in red in B. The overlap of the two statistical maps is presented in C (coronal plane) and D (transverse plane). TFCE images were overlaid on the study-specific MR template with results thresholded at TFCE-corrected p < 0.05.