PMC

Absorption spectra of the ink and dye solutions chromophores used in experimental measurements. Specifically chosen wavelengths are marked with an asterisk.

(a) Dice coefficients for the first simulation set as a function of threshold. (b) Dice coefficients for the second simulation set as a function of threshold.

(a) Dice coefficients for the first experimental set as a function of threshold. (b) Dice coefficients for the second experimental set as a function of threshold.

Reconstruction from both experimental sets, set 1 containing 10% ink and 90% dye and set 2 70% ink and 30% dye.

(a) Absorption spectra for the background, μ_a, and the inclusion, μ_a + Δμ_a, in experimental set 2, containing 70% ink and 30% dye. (b) Contrast between the background and the inclusion for experimental set 2.

(a) Absorption spectra for the background, μ_a, and the inclusion, μ_a + Δμ_a, in experimental set 1, containing 10% ink and 90% dye. (b) Contrast between the background and the inclusion for experimental set 1.

Reconstruction for second set. Middle images are generated with 6 wavelengths and rightmost images are done with 126 wavelengths. Upper row is for the HbO₂ chromophore and the lower for HbR. Concentration units are in mM.

Reconstruction for first set. Middle images are generated with 6 wavelengths and rightmost images are done with 126 wavelengths. Upper row is for the HbO₂ chromophore and the lower for HbR. Concentration units are in mM.

(a) The setup of sources and detectors for simulation reconstructions. Same orientation of axes is used for experimental data. (b) Molar extinction coefficients used in simulations plotted as a function of wavelength.

(a) L-hypersurface, defined by (23) plotted against regularization parameters. (b) H curvature, defined by (24), computed for the L-hypersurface. (c) Error estimation surface, defined by (22), plotted against regularization parameters. The optimal regularization parameters are marked in each case with a red arrow.