Examples of highly clustered modules of heparin/HS-interacting network. HBPs with a high clustering coefficient were extracted together with their first neighbors from the extracellular heparin/HS-interacting network. The node color indicates the clustering coefficient of each node according to the legend. The node label indicates the UniProt short name of the HBP. Protein-protein interactions are represented as green edges. The highest clustering coefficients represented were 1.0 for VEGFB and vascular endothelial growth factor receptor-1 (FLT1) (A), 0.67 for fibrillin-2 (FBN2) (B), 0.60 for coagulation factor IX (F9) (C), and 0.40 for TGFβ2 (D). The graphs were generated using Cytoscape v.2.6.3 (). VWF, von Willebrand factor; CTGF, connective tissue growth factor; ELN, elastin; VTN, vitronectin; APP, amyloid precursor protein. NRP1, neuropilin-1; LTBP-1, latent-transforming growth factor beta-binding protein-1; BMP2, bone morphogenetic protein-2.