PMC

Justification of obtained outcome data

Pubertal development: stage line diagram with SDS plot for girls (n = 30). This figure depicts the SDS values for development of breast (blue lines, five stages), pubic hair (green lines, five stages) and menarche (red lines, yes or no) of 30 girls. The black circles depict the three SDS values for three individual girls, the first circle represents a girl with an early menarche and nearly p90 values for breast and pubic hair, the middle circle represents a girl with p50 development, and the third circle represents a girl with normal menarche but late breast development

Pubertal development; stage line diagram with SDS plot for boys (n = 15). This figure depicts the SDS values for development of genitals (blue lines, five stages), pubic hair (green lines, five stages) and testis (red lines, eight volumes) of 15 boys. The black circles depict the three SDS values for three individual boys, the first circle represents a boy with an early development, almost p99 values for all parameters, the middle circle represents a boy with p50 development, and the third circle represents a boy with late development of all parameters (p5)