PMC

ROC curves of retrieving rhodopsin structures using the experimental cryo-EM density with and without applying the density filter.

The experimental cryo-EM electron density for GroEL (a) and bovine metarhodopsin I (b) and and their best matching structures (c) (d) from searching the PDB. (The figures are prepared using USCF Chimera).

Fingerprint generation from protein structures. (a) The protein structure of staphylococcal nuclease (PDBID: 1stn). (b) Simulated electron density using EMAN. (c) Reconstruction of the electron density using Zernike polynomials up to n = 20. (d) Calculated Zernike invariants up to n = 20 from the protein structure.

Fingerprint difference scores of all the GroEL (a) and rhodopsin (b) protein structures. The distribution of fingerprint differences between the experimental density and all decoy proteins in the datasets are plotted as black solid lines. The fingerprint difference scores for all GroEL and rhodopsin structures are marked using vertical lines.