PMC

A. Study design for allopurinol effects on the development of DOCA-salt hypertension (long-term administration). B. Blood pressure of vehicle (closed symbols) and allopurinol (open symbols)-treated rats, measured by radiotelemetry. Timing of interventions is represented by vertical lines. Data are represented as means ± SEM of 24h average mean arterial pressure (MAP) for N=6.

A. Study design for allopurinol effects on established DOCA-salt hypertension (short-term administration). B. Blood pressure of vehicle (closed symbols) and allopurinol (open symbols)-treated rats, measured by radiotelemetry. Timing of interventions is represented by vertical lines. Data are represented as means ± SEM of 24h average mean arterial pressure (MAP) for N=4.

Hemodynamic parameters: systolic blood pressure (A), diastolic blood pressure (B), pulse pressure (C), and heart rate (D) of DOCA-salt hypertensive rats under long-term treatment with vehicle (closed symbols) and allopurinol (open circles). The vertical line represents the initiation of vehicle or allopurinol treatment. Data are represented as means ± SEM of 24h averages (MAP) for N=6.