PMC

Median lopinavir concentrations during second trimester, third trimester, and postpartum. Median lopinavir concentration–time curves ± interquartile range during the second trimester (long dashed line, n = 11), third trimester (medium dashed line, n = 33), and postpartum (fine dashed line, n = 27). The solid line represents the expected (50th percentile) concentration–time profile in nonpregnant adults.

Lopinavir AUC second trimester, third trimester, and postpartum. Changes in lopinavir area under the concentration–time curves from the second trimester to the third trimester to postpartum (n = 27). The solid line indicates typical value (50th percentile) AUC of tablets in nonpregnant adults of 93 mcg·hr/mL.