PMC

(A) Uptake of quercetin in MiaPaCa-2 cells at different time points as indicated. Values are means ± SEM of 3 separate measurements; (B) Change of quercetin level in cell culture medium with incubation. Preparation of cells and quantitative measurement of quercetin in culture medium at different time points as indicated. Values are means ± SEM of 3 separate measurements (*, P < 0.05, **, P < 0.01).

Change of quercetin and isorhamnetin concentrations in plasma of mice fed a 5% quercetin diet for 8 weeks. Mice were fed with a diet containing 5% of quercetin for 8 weeks, blood were collected and pooled at different time as indicated. Concentrations of quercetin and isorhamnetin in plasma were measured by HPLC as described in Materials and Methods. (A) Plasma absorption of quercetin and isorhamnetin at different time point. (B) Histology of liver and pancreas of nude mice fed with 5% quercetin diet for 8 weeks.