Lack of Cph2p alters murine intestinal colonization. WT (DAY185 or SN100), cph2 deletion mutant, cph2UAU mutant, CPH2 reconstituted null mutant, or tec1UAU mutant were orally inoculated by gavage into Swiss Webster mice. At various days postinoculation, the amounts of C. albicans in fecal pellets were measured. The amounts of C. albicans in organs of the intestinal tract were measured after sacrifice. (A) CFU per gram of fecal pellet. Mice were sampled repeatedly, and each symbol represents a sample from a different mouse. Black triangles, WT C. albicans; black diamonds, cph2 mutant strain; gray diamonds, CPH2 reconstituted strain; bars, geometric means. (B) CFU per gram of organ or organ contents from mice sacrificed on day 21 postinoculation. Each symbol represents a sample from a different mouse. For the stomach and cecum, the colonization in the contents is shown. For the ileum, the contents plus wall were homogenized. Organs are indicated at the top of the graph. Black triangles, WT C. albicans; black diamonds, cph2 mutant strain; open diamonds indicate CFU/g below the limit of detection; gray diamonds, CPH2 reconstituted strain; bars, geometric means. (C) CFU per gram of fecal pellet. Mice were sampled repeatedly, and each symbol represents a sample from a different mouse. Black triangles, WT C. albicans; black diamonds, tec1UAU mutant strain; bars, geometric means.