PMC

Distribution of morbidity (%-of-weeks-ill) during 2-year follow-up following first-lifetime mixed (striped bars) versus manic (gray bars) episodes, comparing time in major or minor mixed-states, major depression or dysthymia, and mania-hypomania-psychosis. All differences between patients starting in mixed-states versus mania are highly significant (all F ≥ 20, all p<0.0001).