PMC

Scatterplot of total hippocampal volume by group. The volumes are corrected for variations in intracranial volume between subjects. PTSD indicates participants with posttraumatic stress disorder.

High-resolution magnetic resonance images of the hippocampus. A, A high-resolution (0.4 × 0.5–mm inplane), T2-weighted magnetic resonance image of the brain shows a coronal section through the hippocampus. The zoomed-in image shows a view of the subfields (B) with the tracings in color superimposed (C). CA indicates cornu ammonis; DG, dentate gyrus; ERC, entorhinal cortex; and S, subiculum.

Scatterplots of volumes of hippocampal subfields and entorhinal cortex by group. All volumes are corrected for variations in intracranial volume between subjects. The CA1/2 transition is not listed because the volumes are very small and difficult to trace compared with the other subfields. CA, cornu ammonis; DG, dentate gyrus; and PTSD, participants with posttraumatic stress disorder.

Depiction of the dissociation between the effects of posttraumatic stress disorder (PTSD) and aging on subfields, separately for cornu ammonis 1 (CA1) and CA3 and the dentate gyrus (CA3/DG). The solid and dashed lines represent regressions of subfield volumes against age by group. This shows a PTSD effect on CA3/DG but not on CA1 after accounting for age.