PMC

Correlation between antibody reactivity to MS and MPT51 in Indian HIV⁻/TB (A), U.S. HIV⁻/TB (B), Indian HIV⁺/TB (C), U.S. HIV⁺/TB (D), U.S. HIV⁻/ORD (E), and U.S. HIV⁺/ORD subjects (F). Spearman rank correlation was used to test for statistical significance.

Antibody reactivities to MS and MPT51 in asymptomatic U.S. control groups categorized by TST result and HIV status. Bars show median ODs with interquartile ranges. The Kruskal-Wallis test was used for the group comparison of median antibody reactivities.

Antibody reactivities to MS and MPT51 by type of ORD. Cutoff values were derived from the mean OD of HIV⁻/TST⁻ healthy volunteers plus 3 standard deviations; ΔOD, change in optical density after the subtraction of the cutoff value; ⧫, HIV⁺; ⋄, HIV⁻; □, HIV status unknown; CAP, community-acquired pneumonia; PCP, Pneumocystis jiroveci pneumonia; NTM, nontuberculous mycobacterial lung disease; bronch, bronchitis; other, respiratory diseases other than TB, such as lung cancer, sarcoidosis, lung abscess, empyema, immune reconstitution syndrome, etc.

Antibody reactivities to MS (A) and MPT51 (B) in subjects with TB, other respiratory diseases (ORD), and controls, categorized by HIV status. Cutoff values were derived from the mean OD of HIV⁻/TST⁻ healthy volunteers plus 3 standard deviations; ΔOD, change in optical density after the subtraction of the cutoff value; •, sputum AFB smear positive; ○, sputum AFB smear negative; Ind, Indian; bars show median ΔODs with interquartile ranges. The Mann-Whitney U test was used for two-group comparisons of median antibody reactivities. *, P < 0.05; **, P < 0.01; ***, P < 0.001.