PMC

Effects of conscientiousness on regional atrophy. A) VLPFC/DLPFC; B) orbitofrontal cortex. Data are standardized residuals controlling for age and education.

Effects of neuroticism on global and regional atrophy. A) cerebral gray matter; B) VLPFC/DLPFC; C) orbitofrontal cortex. Data are standardized residuals controlling for age and education.

Moderation of age effects by neuroticism. A) cerebral white matter, B) amygdala. Plots based on data points estimated using the simple regression equation and represent the age × neuroticism interaction controlling for main effects of age, neuroticism and education (see text for details of regression analysis).

Moderation of age effects by conscientiousness. A) cerebral white matter; B) amygdala, C) parahippocampal gyrus. Plots based on data points estimated using the simple regression equation and represent the significant age × conscientiousness interaction controlling for main effects of age, conscientiousness and education (see text for details of regression analysis.