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1.
Figure 4

Figure 4. From: Hypercholesterolemia induces side-specific phenotype changes and PPAR&[gamma] pathway activation in swine aortic valve endothelium.

Side-specific expression of endothelial proteins in aortic valves exposed to HC for 2 weeks. a. PPAR&[gamma] expression was heterogeneous and confined to the A side endothelium. b. FABP1 was expressed in A side endothelial cells in a heterogeneous distribution.

Marie A. Guerraty, et al. Arterioscler Thromb Vasc Biol. ;30(2):225.

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2.
Figure 2

Figure 2. From: Hypercholesterolemia induces side-specific phenotype changes and PPAR&[gamma] pathway activation in swine aortic valve endothelium.

Pathway analysis of genes up- (red) and down- (green) regulated in HC relative to NC aminals on the aortic side revealed clusters of highly inter-connected CASP3, TGF&[beta], ANXA2, and PPAR&[gamma]-centric genes. Particularly prominent were hypercholerolemia-responsive upstream regulators and downstream targets of PPAR&[gamma].

Marie A. Guerraty, et al. Arterioscler Thromb Vasc Biol. ;30(2):225.

CitationFull text

3.
Figure 5

Figure 5. From: Hypercholesterolemia induces side-specific phenotype changes and PPAR&[gamma] pathway activation in swine aortic valve endothelium.

Aortic side expression of PPAR&[gamma] pathway proteins in normal (NC), 2-week HC, and 6-month HC valves. There is minimal ABCA1, PPAR&[gamma], and FABP1 expression in normal valves. Upon exposure to HC, expression of these proteins is upregulated on the A side endothelium by 2-weeks and persisted at 6-months.

Marie A. Guerraty, et al. Arterioscler Thromb Vasc Biol. ;30(2):225.

CitationFull text

4.
Figure 1

Figure 1. From: Hypercholesterolemia induces side-specific phenotype changes and PPAR&[gamma] pathway activation in swine aortic valve endothelium.

Aortic valve schematic illustrating aortic (black) and ventricular (white) side endothelium (a,upper panel). Hematoxylin and Oil Red O staining shows no lipid insudation in normal valves (a,lower panel); aortic side extra-cellular lipid insudation at 2-weeks HC (b); and increasing extra- and intra-cellular lipid deposition on the aortic side at 6-months HC (c).

Marie A. Guerraty, et al. Arterioscler Thromb Vasc Biol. ;30(2):225.

CitationFull text

5.
Figure 3

Figure 3. From: Hypercholesterolemia induces side-specific phenotype changes and PPAR&[gamma] pathway activation in swine aortic valve endothelium.

Pathway analysis of genes up- (pink) and down- (blue) regulated in A side endothelial cells relative to V side in aortic valves of HC swine. a. TNF&[alpha]-centric pathways were the highest scoring network of differentially expressed genes. b. TNF&[alpha] and NF&[kappa]B pathways were downregulated by hypercholesterolemia.

Marie A. Guerraty, et al. Arterioscler Thromb Vasc Biol. ;30(2):225.

CitationFull text

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