PMC

Effects of knockdown of PER1, PER2, and CLOCK expression in the SCN on VIP content in punches of both the SCN (a) and the PVN (b). * p < 0.05 AS-ODN vs. RS-ODN group (1-way ANOVA followed by Newman-Keuls’ test).

Effects of knockdown of PER1, PER2, and CLOCK expression in the SCN on the DOPAC:DA ratio levels of the ME (a), IL of the pituitary (b), and NL of the pituitary (c), as well as on plasma PRL levels (d). ^a p < 0.05 AS-ODN vs. RS-ODN group (1-way ANOVA followed by Newman-Keuls’ test); ^b p < 0.05, 12.00 vs. 17.00 h (1-way ANOVA followed by Newman-Keuls’ test).

Effects of PER1, PER2, and CLOCK expression knockdown in the SCN on the profile of plasma PRL secretion induced by cervical stimulation in OVX rats. A cocktail of either AS-ODN or RS-ODN for clock genes was injected into the SCN, and blood samples were taken the following day. ^a p < 0.05, RS-ODN (17.00 and 03.00 h) vs. RS-ODN (other times) (one-way ANOVA followed by Bonferroni's test); ^b p < 0.001, AS-ODN vs. RS-ODN (2-way ANOVA followed by Bonferroni's test). There were no differences among times within AS-ODN.