PMC

Quantitative baseline DTPA GFR correlations in infants with SCA. A, DTPA GFR compared with age, with GFR increasing in older infants, N=176, r²=0.058, p=0.0013. B, DTPA GFR compared with the estimated Schwartz GFR, showing a positive correlation but wide variation, N=157, r²=0.0658, p=0.0012, slope = 0.169.

Quantitative GFR analysis by DTPA clearance in the BABY HUG trial. A total of 233 infants were initially screened for eligibility, 40 of whom failed screening. Reasons for inadequate or uninterpretable DTPA results were variable but included poor venous access, extravasated radionuclide, and difficulties with blood collection. A total of 176/191 DTPA attempts (92%) were successful with interpretable results.