PMC

Scatter plot showing the relationship between pharmacogenetic-predicted efavirenz mid-dose plasma concentrations (y-axis) and observed concentration (x-axis) in 94 HIV-infected patients. Log₁₀ efavirenz mid-dose plasma concentrations predictions for each subject were made based on their genotype carrier status (CYP2B6 c.516TT, CYP2A6*9 or *17 and/or UGT2B7*1a as indicated by arrows) using the pharmacogenetic algorithm derived by multiple linear regression analysis (model and associated goodness of fit statistics are shown at the top of graph). Log₁₀ efavirenz concentration units are back-transformed into linear units for presentation in the plot.