PMC

MRI acquired 24 h after CED, depicting significant bilateral hydrocephalus and unilateral occipital liquid accumulation. The diffusion-weighted MRIs and the calculated apparent diffusion coefficient maps (on the right) show no tissue toxicity.

Histology slide of a rat treated with CED of PRX321. Hemosiderin-laden macrophages with no architectural disruption can be seen along the catheter path in the cortex (a). Structural changes can be seen in the hippocampus (b). No abnormalities in the striatum (c).

Examples of poor, moderate, and efficient infusate distributions in the rat brain, as depicted by T1-weighted MRI acquired immediately after CED with Gd-containing infusates. The rat brain presented in the top image was treated with infusate 1; the rats presented in the middle and bottom images were treated with infusate 4.