PMC

PET images of upper and lower lobe lung lesions (indicated by arrows) of an 80-year old Asian female patient. Red to white colors indicates high to low density.

Metabolite concentration in normal, upper and lower lobe lung nodules.
Myo-inositol (Ino), glucose (Glc), phosphocholine (PCh) were quantified from ¹H NMR spectra in while the other metabolites were quantified by GC-MS as described previously (). Lac: lactate; α-G3P: α-glycerol-3-phosphate; Suc: succinate; Fum: fumarate; Cit: citrate. UL upper lobe, LL lower lobe

¹H NMR spectra of extracts of paired normal and lung lesions.
Flash frozen slices from upper lobe (UL, top panel), lower lobe (LL, middle panel) nodules, and non-cancerous tissues (bottom panel) were taken from the resected lung of the patient shown in , and extracted with 10% TCA and ¹H NMR spectra of extracts were recorded at 600 MHz. Metabolite assignments were based on our in-house database, 2-D ¹H TOCSY and ¹H-¹³C HSQC NMR spectra (not shown) (). The three spectra were normalized in terms of tissue weight and NMR spectral parameters for direct comparison.