PMC

mRNA can exist in at least 3 states in the cytoplasm- Polysomes, P bodies and Stress granules. Recruitment of translational repressors such as Dhh1 and Pat1 facilitate the movement of mRNA into a non-translating state. Kinetic competition ensues between ribosome run-off, recruitment of decapping machinery, decapping followed by transcript degradation and aggregation into a P body. mRNAs complexed with the decapping machinery can be degraded, aggregate into a P body, or enter back into translation. Limiting conditions of translation initiation may be overcome by aggregation into Stress granules where local concentration of translation apparatus is high.