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1.
Figure 2

Figure 2. Effect of vincristine with or without rMETase on NB cell proliferation of SK-N-BE(1)N and SK-N-LD. From: Methionine depletion with recombinant methioninase: In vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.

Open circle: vincristine alone; Solid triangle: rMETase + vincristine combined treatment.

Jian Hu, et al. Int J Cancer. ;124(7):1700-1706.

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2.
Figure 4

Figure 4. Efficacy of in vivo rMETase in NB xenografts. From: Methionine depletion with recombinant methioninase: In vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.

Open square: Control (N=10 for LAN-1 and N=26 for NMB-7); Solid circle: rMETase treatment (N=10 for LAN-1 and N=34 for NMB-7); ** p<0.01 when AUC of rMETase group was compared to the control group.

Jian Hu, et al. Int J Cancer. ;124(7):1700-1706.

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3.
Figure 1

Figure 1. Molecular size and purity of rMETase. From: Methionine depletion with recombinant methioninase: In vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.

A: SDS-PAGE. Lane 1: Purified rMETase; Lane 2: Supernatant from whole cell extract; Lane 3: Whole cell crude extract, Lane 4: Marker.
B: HPLC size exclusion profile of purified rMETase. The major peak at 15.547 min was rMETase.

Jian Hu, et al. Int J Cancer. ;124(7):1700-1706.

CitationFull text

4.
Figure 5

Figure 5. Efficacy of in vivo combination treatment with rMETase and vincristine. From: Methionine depletion with recombinant methioninase: In vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.

Open square: Control (N=9 for LAN-1 and NMB-7); Solid circle: rMETase alone (N=14 for LAN-1 and N=7 for NMB-7); Open circle: vincristine alone (N=8 for LAN-1 and N=7 for NMB-7); Solid triangle: rMETase + vincristine combined treatment (n=14 for LAN-1 and n=13 for NMB-7); ** p<0.001 when AUC of combination group was compared to other 3 groups, respectively.

Jian Hu, et al. Int J Cancer. ;124(7):1700-1706.

CitationFull text

5.
Figure 3

Figure 3. Effect of rMETase with or without vincristine on cell cycle arrest of SK-N-BE(2)C. From: Methionine depletion with recombinant methioninase: In vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.

The flow cytometry results were presented in density plots, where the quadrants were set to include live cells. The lower left quadrant contained G1 phase population; the lower right quadrant contained G2 phase population; the upper right quadrant contained M phase population.

Jian Hu, et al. Int J Cancer. ;124(7):1700-1706.

CitationFull text

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