Estimated cumulative incidence of further 3-step progression of retinopathy from Diabetes Control and Complications Trial (DCCT) closeout to Epidemiology of Diabetes Interventions and Complications (EDIC) study year 10 (n=1349) (A) and from DCCT closeout to EDIC year 4 (n=1320) and from EDIC year 4 to EDIC year 10 (n=1105) (B) based on Weibull regression models adjusted for the level of retinopathy at the end of the DCCT, primary vs secondary cohort, glycated hemoglobin value on entry to the DCCT, and diabetes mellitus duration at DCCT baseline. Retinopathy was evaluated in 369 patients during EDIC year 1, 448 in year 2, 430 in year 3, 1225 in year 4 (1997), 338 in year 5, 440 in year 6, 406 in year 7, 204 in year 8, 233 in year 9, and 1211 in year 10 (2003). Subjects with prior scatter photocoagulation during the DCCT were excluded from analyses (26 in the conventional therapy group and 10 in the intensive therapy group). Patients who had further 3-step progression from DCCT closeout as of EDIC year 4 (n=212) and patients who were censored during the interval (n=32) were excluded from the analysis of incidence over years 4 to 10. CI indicates confidence interval.