PMC

Fig 4 Results of sensitivity analysis. Effect of changing each parameter over its range on estimated cost effectiveness of base case programme (estimates derived from regression model). 95% end points of range of each parameter are also shown

Fig 3 Cost effectiveness acceptability curves for vaccination of girls aged 12 years with a quadrivalent vaccine at different levels of three dose coverage, for different assumptions about duration of protection from vaccine. Incremental cost effectiveness of vaccination compared with no vaccination option is shown. Region of £20 000-£30 000 per QALY gained is shaded

Fig 2 Cost effectiveness acceptability curves for vaccination of girls aged 12, 13, or 14 years with a quadrivalent vaccine at 80% coverage, under different assumptions about vaccine duration of protection, based on results of 50 000 meta-scenarios combining epidemiological and economic assumptions. Incremental cost effectiveness of vaccination compared with no vaccination option is shown. Region of £20 000-£30 000 per QALY gained is shaded

Fig 1 Cost effectiveness acceptability curves for base case vaccination programme (girls aged 12 years only, quadrivalent vaccine, 80% coverage) under different assumptions about duration of protection from vaccine. Incremental cost effectiveness of vaccination compared with no vaccination option is shown. Region of £20 000- £30 000 per QALY gained is shaded. Thick solid and dashed lines indicate cost effectiveness acceptability curves when considering vaccine type cervical cancers in a screened population, medium solid and dashed lines indicate curves assuming 80% coverage in screened and unscreened populations, and thin solid and dashed lines indicate curves assuming 80% coverage in screened and unscreened populations, protection against non-cervical cancers, and some cross protection against non-vaccine types