PMC

Urinary sodium excretion in the same rats in .

Mean arterial pressure during baseline conditions and 12 days of diabetes in normal rats and rats treated continuously with L-NAME .

Glomerular filtration rate in rats during a control period and once per week over a 3-week diabetic period. The Diabetes + L-NAME rats received L-NAME continuously, iv, throughout the experiment .

Mean arterial pressure in rats with normal kidneys or a 70% reduction in kidney mass, with or without chronic ACE inhibition, during baseline conditions, a 7-day diabetic period, and a recovery period .

Transfer function (TF) gain for dynamic renal blood flow autoregulation in control rats diabetic rats, during the baseline period (top panel) and the diabetic period (bottom panel). The “TGF” and “Myogenic” labels denote the approximate frequency ranges at which the respective autoregulatory mechanisms operate. The oval circle illustrates the impairment in TGF in the diabetic rats.

Tubuloglomerular feedback as determined by measuring single nephron GFR, or an index, in response to changes in tubular flow, or perfusion rate. Bottom dashed line represents the resetting and increased sensitivity measured in response to NO synthesis inhibition ,, and the top dashed line shows the effect of increased NO levels as estimated by the response to administration of NO donors , Comparing point B to point A shows that with increased NO levels and decreased TGF sensitivity, there will be a greater GFR for any given level of tubular flow rate.