Image sections obtained with Statistical Parametric Mapping software (SPM2) (Wellcome Department of Imaging Neuroscience, London, England) illustrating α-methylparatyrosine (AMPT)-induced metabolic changes and correlations between AMPT-induced symptoms and regional metabolism displayed on an anatomic magnetic resonance image of the brain in the SPM2 analyses of the combined samples (N=28). A, Metabolism increased after AMPT treatment in the bilateral anteroventral striatum, as shown by voxel t values (in color bar) corresponding to P<.001; the crosshair of the lower images does not correspond to a particular peak. B, Reductions in metabolism after AMPT treatment in the left orbitofrontal cortex, as shown by voxels with t corresponding to P<.001 in the medial orbital gyrus. C, Area where changes in metabolism correlated with AMPT-induced depressive symptoms (rated by the Montgomery-Asberg Depression Rating Scale [MADRS]) in the ventromedial frontal polar cortex, as shown by voxel t values corresponding to P<.001 in the correlational analysis. D, Area where glucose utilization correlated with AMPT-induced anhedonia (rated by negative scores from the Snaith-Hamilton Pleasure Scale [SHAPS]) in the right accumbens area, shown as voxel t values corresponding to P<.005. Stereotaxic coordinates corresponding to the horizontal and vertical axes (shown in blue) are listed to the left of each image set and are interpreted as in .