PMC

Serotype vaccine coverage according to age group for penicillin and erythromycin non-susceptible strains. (a) Percentage of strains with serotypes included in the vaccine formulations (SVF), according to age group for penicillin non-susceptible strains. (b) Percentage of strains with SVF, according to age group for erythromycin non-susceptible strains. (c) Percentage of strains with SVF, according to age group for susceptible and non-susceptible strains.

Observed annual rates (1994–2004) of antimicrobial non-susceptible pneumococci isolated from invasive disease in Portugal and respective linear regression models. (a) Observed (■) and predicted (–△–) annual rates of penicillin non-susceptible strains for children (PC). (b) Observed (■) and predicted (–△–) annual rates of penicillin non-susceptible strains for adults (PA). (c) Observed (■) and predicted (–△–) annual rates of erythromycin non-susceptible strains for children (EC). (d) Observed (■) and predicted (–△–) annual rates of erythromycin non-susceptible strains for adults (EA). (e) Scenarios for annual rates of penicillin non-susceptible strains for children: predicted (–△–) without vaccine (–×–), without azithromycin use (–◊–), without vaccine and azithromycin use (–+–).

Distribution of non-susceptible strains to penicillin and erythromycin by pneumococci serotypes isolated from invasive disease in Portugal between years 1999 and 2002. (a) Distribution of non-susceptible strains to penicillin by serotypes isolated from children aged <2 years (□) and <18 years (■). (b) Distribution of non-susceptible strains to penicillin by serotypes isolated from adults aged ⩾18 years (■) and ⩾65 years (□). (c) Distribution of non-susceptible strains to erythromycin by serotypes isolated from children aged <2 years (□) and <18 years (■). (d) Distribution of non-susceptible strains to erythromycin by serotypes isolated from adults aged ⩾18 years (■) and ⩾65 years (□).