PMC

Photographs of representative mice with HemCon or alginate bandages.

Comparison of adhesion times of HemCon and alginate bandages to infected mouse wounds.

Survival curves of mice with P. aeruginosa infection treated with HemCon (n = 8), alginate (n = 6), AgSD (n = 20), or no treatment (n = 8).

Survival curves of mice with P. mirabilis infection treated with HemCon (n = 8), alginate (n = 12), AgSD (n = 10), or no treatment (n = 10).

Mean bioluminescence values (bars = SEM) of cyclophosphamide-treated mice with S. aureus infection treated with HemCon, alginate, or no treatment. ***, P < 0.001; **, P < 0.01 vs. all other treatments.

Mean bioluminescence values (bars = SEM) of mice with P. mirabilis infection treated with HemCon, alginate, AgSD, or no treatment. ***P < 0.001; **P < 0.01 vs. all other treatments.

Representative bioluminescence images at same bit range of mice with P. mirabilis-infected wounds with treated HemCon (A–D), alginate (E–H), or no treatment control (J–L). Panel (M) shows overnight incubation of blood sample from moribund mouse demonstrating bioluminescent bacteremia.

Mean bioluminescence values (bars = SEM) of mice with P. aeruginosa infection treated with HemCon, alginate, AgSD, or no treatment. ***, P < 0.001 vs. no treatment and alginate. HemCon was only significantly different from AgSD (P < 0.01) at 24 and 36 h.

In vitro antimicrobial effects of dissolved HemCon bandage. Bacteria (10⁸/mL) were incubated with a 1% aqueous solution of HemCon bandage (pH = 4.5) or with a control acetate buffer (pH = 4.5) and aliquots withdrawn at the indicated times for determination of CFU. Points are means of three independent determinations and bars are SEM.