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Figure 1

Figure 1. From: Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension.

Mean plasma concentration-time curves for (A) sildenafil and (B) desmethylsildenafil following administration of sildenafil 100 mg alone (▴) after 4 weeks’ bosentan 62.5 mg b.d. (×) and after 4 weeks’ bosentan 125 mg b.d. (•). n = 10

Gideon A Paul, et al. Br J Clin Pharmacol. 2005 Jul;60(1):107-112.

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