FIGURE 1. University of Michigan algorithm for treatment of severe ARDS. PIP, plateau inspiratory pressure; PEEP, positive end-expiratory pressure; FiO2, fraction of inspired oxygen; SaO2, arterial oxygen saturation; SvO2, mixed venous oxygen saturation; I:E, inspiratory to expiratory; Hct, hematocrit; PRBC's, packed red blood cells; CVVH, continuous veno-venous hemofiltration; ECLS, extracorporeal life support.