PMC

Map integration of rat chromosome 16 cytogenetic, genome, and radiation hybrid provides reference information for orienting QTLs from multiple studies.

Functional alignment of updated release of the rat radiation hybrid map RH version 3.4 aligned with the original RH version 2.1 used for quality control.

Display of rat Chr 14 (center) and syntenic regions in human Chr 4, 22 and 2 (left) and mouse Chr 5 and 11 (right).

Current rat genome build (version 3.1) and earlier builds can be aligned with either genetic maps (data not shown), previous genome assemblies (version 2.1 shown), or the radiation hybrid map (RH 3.4) for overall review and quality control.

The Integrated Physiological Genomics Environment and VCMapView support a comparative strategy, allowing the biology mapped to organism one (e.g., QTLs, genes) to be translated to the genome and to syntenic regions in organisms 2 and 3 via the comparative maps

An example of integrated physiological genomics connecting 10 induced arthritis QTLs from rat Chr 10 to four arthritis QTLs in the syntenic region of mouse Chr 11. QTLs mapped in both organisms are integrated by using the respective genome and comparative maps; the maps used are labeled in the grey bar at the top of the figure.