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1.
Figure 3

Figure 3. From: Lung pathology of fatal severe acute respiratory syndrome.

SARS-CoV pneumonia with cytomegaly of pneumocytes
Haematoxylin and eosin; ×400.

John M Nicholls, et al. Lancet. 2003 May 24;361(9371):1773-1778.
2.
Figure 2

Figure 2. From: Lung pathology of fatal severe acute respiratory syndrome.

SARS showing hyaline-membrane formation and pneumocyte desquamation with focal giant-cell formation
Haematoxylin and eosin; ×400.

John M Nicholls, et al. Lancet. 2003 May 24;361(9371):1773-1778.
3.
Figure 5

Figure 5. From: Lung pathology of fatal severe acute respiratory syndrome.

Squamous metaplasia of bronchial mucosa in SARS-CoV pneumonia
Haematoxylin and eosin; ×400.

John M Nicholls, et al. Lancet. 2003 May 24;361(9371):1773-1778.
4.
Figure 4

Figure 4. From: Lung pathology of fatal severe acute respiratory syndrome.

CD68 macrophage antibody staining of giant cells in patient 5
Diaminobenzidine with haematoxylin counterstain; ×400.

John M Nicholls, et al. Lancet. 2003 May 24;361(9371):1773-1778.
5.
Figure 7

Figure 7. From: Lung pathology of fatal severe acute respiratory syndrome.

Thin-section electron micrograph showing a dilated secretory vesicle containing a 90 nm coronavirus particle
×63 000.

John M Nicholls, et al. Lancet. 2003 May 24;361(9371):1773-1778.
6.
Figure 1

Figure 1. From: Lung pathology of fatal severe acute respiratory syndrome.

Open lung biopsy from patient 4
Arrow shows an enlarged pneumocyte with amphophilic granular cytoplasm and prominent nucleolus. Haematoxylin and eosin; ×400.

John M Nicholls, et al. Lancet. 2003 May 24;361(9371):1773-1778.
7.
Figure 6

Figure 6. From: Lung pathology of fatal severe acute respiratory syndrome.

Septal inflammation of patient 2
A: Increased numbers of mononuclear cells with haemophagocytosis. Haematoxylin and eosin; ×400. B: The mononuclear cells are CD68 positive. Diaminobenzidine with haematoxylin counterstain.

John M Nicholls, et al. Lancet. 2003 May 24;361(9371):1773-1778.

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