PMC

Functional recovery assessed by the percentage of maximum dP/dt from its pre-ischeamic value, during low-flow ischaemia (0.6 ml min⁻¹, 90 min)-reperfusion (60 min) sequence. (A) Control or endotoxic hearts (LPS 10 μg kg⁻¹, i.v, 24 h earlier) are perfused or not with either SR 141716A (1 μM), SR 144528 (1 μM), or NNLA (30 μM). (B) Control hearts are perfused or not with SNP, in absence or in presence of either SR 141716A (1 μM), or SR 144528 (1 μM). Drug perfusions are initiated 5 min before ischaemia and maintained during the entire ischaemic period. Values are mean±s.e.mean. ^*P<0.05 vs control group.

Infarct size expressed as the percentage of ventricular area assessed following low-flow ischaemia (0.6 ml min⁻¹, 90 min)-reperfusion (60 min) sequence, in: (A) control or endotoxic hearts (LPS 10 μg kg⁻¹, i.v. 24 h earlier), perfused or not with either SR 141716A (1 μM), SR 144528 (1 μM), or NNLA (30 μM). (B) control hearts perfused or not with SNP, in absence or in presence of either SR 141716A (1 μM), or SR 144528 (1 μM). Drug perfusions are initiated 5 min before ischaemia and maintained during the entire ischaemic period. Open circles, individual values, and closed circles, mean±s.e.mean. ^*P<0.05 vs control group.