Fig. 1. Sequence relationship of putative human, S.cerevisiae, S.pombe, D.melanogaster and C.elegans PP2A carboxyl methyltransferases. Predicted amino acid sequences of human methyltransferases (hsmt1, AAF18267; hsmt2, BAA25473) and those of related proteins predicted from the genomic sequences of S.cerevisiae (PPM1, YDR435c; PPM2, YOL141w), S.pombe (spmt1, CAA21793; spmt2, CAA19576), D.melanogaster (dmmt, AAF53483) and C.elegans (cemt, CAA84295) are aligned using the PILEUP program from the University of Wisconsin GCG.