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Select item 110166421.

A Phase 1b/2a Study of GC1118 with 5-Fluorouracil, Leucovorin and Irinotecan (FOLFIRI) in Patients with Recurrent or Metastatic Colorectal Cancer

Keun-Wook Lee, Sae-Won Han, Tae Won Kim, Joong Bae Ahn, Ji Yeon Baek, Sang Hee Cho, Howard Lee, Jin Won Kim, Ji-Won Kim, Tae-You Kim, Yong Sang Hong, Seung-Hoon Beom, Yongjun Cha, Yoonjung Choi, Seonhui Kim, Yung-Jue Bang

Cancer Res Treat. 2024 Apr; 56(2): 590–601. Published online 2023 Dec 7. doi: 10.4143/crt.2023.1117

PMCID:: PMC11016642

Abstract Article PDF–1.9M

Select item 109440992.

Impact of KRAS^G12 mutations on survival with trifluridine/tipiracil plus bevacizumab in patients with refractory metastatic colorectal cancer: post hoc analysis of the phase III SUNLIGHT trial

J. Tabernero, J. Taieb, M. Fakih, G.W. Prager, E. Van Cutsem, F. Ciardiello, R.J. Mayer, N. Amellal, D. Skanji, E. Calleja, T. Yoshino

ESMO Open. 2024 Mar; 9(3): 102945. Published online 2024 Mar 11. doi: 10.1016/j.esmoop.2024.102945

PMCID:: PMC10944099

Abstract Article PDF–468K

Select item 109408523.

Transverse Colon Primary Tumor Location as a Biomarker in Metastatic Colorectal Cancer: A Pooled Analysis of CCTG/AGITG CO.17 and CO.20 Randomized Clinical Trials

Joao Paulo Solar Vasconcelos, Nan Chen, Emma Titmuss, Dongsheng Tu, Stephanie Y. Brule, Rachel Goodwin, Derek J. Jonker, Timothy Price, John R. Zalcberg, Malcolm J. Moore, Christos S. Karapetis, Lillian Siu, Jeremy Shapiro, John Simes, Sharlene Gill, Chris J. O'Callaghan, Jonathan M. Loree

Clin Cancer Res. 2024 Mar 15; 30(6): 1121–1130. Published online 2024 Jan 3. doi: 10.1158/1078-0432.CCR-23-3275

PMCID:: PMC10940852

Abstract Article PDF–4.9M

Select item 108261384.

Efficacy, safety and genomic analysis of SCT200, an anti-EGFR monoclonal antibody, in patients with fluorouracil, irinotecan and oxaliplatin refractory RAS and BRAF wild-type metastatic colorectal cancer: a phase Ⅱ study

Lin Yang, Wen Zhang, Nanfeng Fan, Peiguo Cao, Ying Cheng, Lingjun Zhu, Suxia Luo, Hong Zong, Yuxian Bai, Jianfeng Zhou, Yanhong Deng, Yi Ba, Tianshu Liu, Mayinuer Aili, Xianli Yin, Kangsheng Gu, Guanghai Dai, Jieer Ying, Jianhua Shi, Yajie Gao, Wei Li, Guohua Yu, Liangzhi Xie, Wenlin Gai, Yan Wang, Peng Meng, Yuankai Shi

eBioMedicine. 2024 Feb; 100: 104966. Published online 2024 Jan 13. doi: 10.1016/j.ebiom.2024.104966

PMCID:: PMC10826138

Abstract Article PDF–1.0M

Select item 105179475.

Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer

Lucia Taraborrelli, Yasin Şenbabaoğlu, Lifen Wang, Junghyun Lim, Kerrigan Blake, Noelyn Kljavin, Sarah Gierke, Alexis Scherl, James Ziai, Erin McNamara, Mark Owyong, Shilpa Rao, Aslihan Karabacak Calviello, Daniel Oreper, Suchit Jhunjhunwala, Guillem Argiles, Johanna Bendell, Tae Won Kim, Fortunato Ciardiello, Matthew J. Wongchenko, Frederic J. de Sauvage, Felipe de Sousa e Melo, Yibing Yan, Nathaniel R. West, Aditya Murthy

Nat Commun. 2023; 14: 5945. Published online 2023 Sep 23. doi: 10.1038/s41467-023-41618-7

PMCID:: PMC10517947

Abstract Article PDF–2.2M

Select item 104615156.

Mutant PIK3CA as a negative predictive biomarker for treatment with a highly selective PIM1 inhibitor in human colon cancer

Yoon Sun Park, Joseph kim, Yea Seong Ryu, Jai-Hee moon, Yu Jin shin, Jeong Hee kim, Seung-Woo hong, Soo-A jung, Seul lee, Seung-Mi kim, Dae Hee lee, Do Yeon kim, Hyeseon yun, Ji-Eun you, Dong Il yoon, Chul Hee kim, Dong-In koh, Dong-Hoon jin

Cancer Biol Ther. 2023; 24(1): 2246208. Published online 2023 Aug 24. doi: 10.1080/15384047.2023.2246208

PMCID:: PMC10461515

Abstract Article PDF–2.0M

Select item 103549667.

Sintilimab plus bevacizumab and CapeOx (BBCAPX) on first-line treatment in patients with RAS mutant, microsatellite stable, metastatic colorectal cancer: study protocol of a randomized, open-label, multicentric study

Xuefeng Fang, Chenhan Zhong, Shanshan Weng, Hanguang Hu, Jian Wang, Qian Xiao, Jianwei Wang, Lifeng Sun, Dong Xu, Xiujun Liao, Caixia Dong, Suzhan Zhang, Jun Li, Kefeng Ding, Ying Yuan

BMC Cancer. 2023; 23: 676. Published online 2023 Jul 18. doi: 10.1186/s12885-023-11139-z

PMCID:: PMC10354966

Abstract Article PDF–1.1M

Select item 102655978.

Establishment of patient-derived tumor organoids to functionally inform treatment decisions in metastatic colorectal cancer

G. Martini, V. Belli, S. Napolitano, V. Ciaramella, D. Ciardiello, A. Belli, F. Izzo, A. Avallone, F. Selvaggi, F. Menegon Tasselli, W. Santaniello, R. Franco, I. Puig, L. Ramirez, I. Chicote, F. Mancuso, G. Caratu, X. Serres, R. Fasani, J. Jimenez, J. Ros, I. Baraibar, N. Mulet, C.M. Della Corte, T. Troiani, A. Vivancos, R. Dienstmann, E. Elez, H.G. Palmer, J. Tabernero, E. Martinelli, F. Ciardiello, G. Argilés

ESMO Open. 2023 Jun; 8(3): 101198. Published online 2023 Apr 27. doi: 10.1016/j.esmoop.2023.101198

PMCID:: PMC10265597

Abstract Article PDF–635K

Select item 94381899.

Multicentre single-arm phase II trial evaluating the safety and effiCacy of Panitumumab and iRinOtecan in NeoRAS Wild-type mEtaStatic colorectal cancer patientS (C-PROWESS trial): study protocol

Hiroki Osumi, Naoki Ishizuka, Atsuo Takashima, Yosuke Kumekawa, Daisuke Nakano, Manabu Shiozawa, Tadamichi Denda, Ryoichi Sawada, Kota Ouchi, Takeru Wakatsuki, Boku Narikazu, Ken Kato, Kensei Yamaguchi, Eiji Shinozaki

BMJ Open. 2022; 12(9): e063071. Published online 2022 Sep 1. doi: 10.1136/bmjopen-2022-063071

PMCID:: PMC9438189

Abstract Article PDF–303K

Select item 932161310.

Gut microbiota correlates with antitumor activity in patients with mCRC and NSCLC treated with cetuximab plus avelumab

Giulia Martini, Davide Ciardiello, Marcello Dallio, Vincenzo Famiglietti, Lucia Esposito, Carminia Maria Della Corte, Stefania Napolitano, Morena Fasano, Antonietta Gerarda Gravina, Marco Romano, Carmelina Loguercio, Alessandro Federico, Evaristo Maiello, Concetta Tuccillo, Floriana Morgillo, Teresa Troiani, Massimo Di Maio, Erika Martinelli, Fortunato Ciardiello

Int J Cancer. 2022 Aug 1; 151(3): 473–480. Published online 2022 Apr 29. doi: 10.1002/ijc.34033

PMCID:: PMC9321613

Abstract Article PDF–739K

Select item 927151411.

Effect of KRAS codon 12 or 13 mutations on survival with trifluridine/tipiracil in pretreated metastatic colorectal cancer: a meta-analysis

T. Yoshino, E. Van Cutsem, J. Li, L. Shen, T.W. Kim, V. Sriuranpong, L. Xuereb, P. Aubel, R. Fougeray, V. Cattan, N. Amellal, A. Ohtsu, R.J. Mayer

ESMO Open. 2022 Jun; 7(3): 100511. Published online 2022 Jun 7. doi: 10.1016/j.esmoop.2022.100511

PMCID:: PMC9271514

Abstract Article PDF–508K

Select item 922568012.

Pertuzumab Plus Trastuzumab for Treatment-Refractory HER2-Amplified Metastatic Colorectal Cancer: Comparison of the MyPathway Trial With a Real-World External Control Arm

Yusuke Narita, Takuya Yoshimoto, Tomoyuki Namai, Takashi Asakawa, Satoe Kawakami, Craig Gower-Page, Irmarie Reyes-Rivera, Arisha Patel, Yoshiaki Nakamura

JCO Clin Cancer Inform. 2022; 6: e2200022. Published online 2022 Jun 1. doi: 10.1200/CCI.22.00022

PMCID:: PMC9225680

Abstract Article PDF–308K

Select item 885860813.

PRKAR2A‐derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis‐associated colorectal cancer

Daiwei Wan, Sentai Wang, Zhihua Xu, Xinquan Zan, Fei Liu, Ye Han, Min Jiang, Airong Wu, Qiaoming Zhi

Clin Transl Med. 2022 Feb; 12(2): e683. Published online 2022 Feb 20. doi: 10.1002/ctm2.683

PMCID:: PMC8858608

Abstract Article PDF–5.1M

Select item 835151614.

Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review

Yang An, Jiaolin Zhou, Guole Lin, Huanwen Wu, Lin Cong, Yunhao Li, Xiaoyuan Qiu, Weikun Shi

Pathol Oncol Res. 2021; 27: 1609859. Published online 2021 Jul 26. doi: 10.3389/pore.2021.1609859

PMCID:: PMC8351516

Abstract Article PDF–1.1M

Select item 746966915.

Thrombospondin-1 counteracts the p97 inhibitor CB-5083 in colon carcinoma cells

Nam-Gu Her, Santosh Kesari, Elmar Nurmemmedov

Cell Cycle. 2020; 19(13): 1590–1601. Published online 2020 May 19. doi: 10.1080/15384101.2020.1754584

PMCID:: PMC7469669

Abstract Article PDF–2.1M

Select item 726124816.

Immunotherapy After Immunotherapy: Response Rescue in a Microsatellite Instability-High Colorectal Cancer Patient Post-Pembrolizumab

Satya Das, Audrey Allen, Jordan Berlin

Clin Colorectal Cancer. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Clin Colorectal Cancer. 2020 Jun; 19(2): 137–140. Published online 2020 Feb 8. doi: 10.1016/j.clcc.2020.02.006

PMCID:: PMC7261248

Abstract Article PDF–2.0M

Select item 696879517.

Nivolumab Is Effective in Mismatch Repair–Deficient Noncolorectal Cancers: Results From Arm Z1D—A Subprotocol of the NCI-MATCH (EAY131) Study

Nilofer S. Azad, Robert J. Gray, Michael J. Overman, Jonathan D. Schoenfeld, Edith P. Mitchell, James A. Zwiebel, Elad Sharon, Howard Streicher, Shuli Li, Lisa M. McShane, Larry Rubinstein, David R. Patton, P. Mickey Williams, Brent Coffey, Stanley R. Hamilton, Nathan Bahary, J. Marie Suga, Hassan Hatoum, Jeffrey S. Abrams, Barbara A. Conley, Carlos L. Arteaga, Lyndsay Harris, Peter J. O'Dwyer, Alice P. Chen, Keith T. Flaherty

J Clin Oncol. 2020 Jan 20; 38(3): 214–222. Published online 2019 Nov 25. doi: 10.1200/JCO.19.00818

PMCID:: PMC6968795

Abstract Article PDF–912K

Select item 672164718.

Whole Transcriptome Analysis Identifies TNS4 as a Key Effector of Cetuximab and a Regulator of the Oncogenic Activity of KRAS Mutant Colorectal Cancer Cell Lines

Sujin Kim, Nayoung Kim, Keunsoo Kang, Wonkyung Kim, Jonghwa Won, Jeonghee Cho

Cells. 2019 Aug; 8(8): 878. Published online 2019 Aug 12. doi: 10.3390/cells8080878

PMCID:: PMC6721647

Abstract Article PDF–1.2M

Select item 640066319.

KRAS-mutant colon cancer cells respond to combined treatment of ABT263 and axitinib

Guihua Wang, Ying Huang, Zhipeng Wu, Chunmei Zhao, Hui Cong, Shaoqing Ju, Xudong Wang

Biosci Rep. 2019 Mar 29; 39(3): BSR20181786. Prepublished online 2019 Jan 23. Published online 2019 Mar 6. doi: 10.1042/BSR20181786

PMCID:: PMC6400663

Abstract Article PDF–906K

Select item 630033820.

Unusually long-term responses to vemurafenib in BRAF V600E mutated colon and thyroid cancers followed by the development of rare RAS activating mutations

Tali Ofir Dovrat, Ethan Sokol, Garrett Frampton, Eliya Shachar, Sharon Pelles, Ravit Geva, Ido Wolf

Cancer Biol Ther. 2018; 19(10): 871–874. Published online 2018 Jul 23. doi: 10.1080/15384047.2018.1480289

PMCID:: PMC6300338

Abstract Article PDF–518K

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