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Items: 1 to 20 of 80

1.
Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell Development and Senescence
Shasha Chen, Zehua Li, Jin Feng, Yuhe Quan, Junming He, Jiqing Hao, Zhongjun Dong
Adv Sci (Weinh) 2024 Jun; 11(21): 2309315. Published online 2024 Mar 27. doi: 10.1002/advs.202309315
PMCID:
PMC11151045
AbstractArticlePDF–8.3M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin)
Kehan Wang, Feifei Kong, Yuexin Qiu, Tao Chen, Jiayi Fu, Xin Jin, Youqiang Su, Yayun Gu, Zhibin Hu, Jing Li
Autophagy. 2023; 19(11): 2934–2957. Published online 2023 Jul 14. doi: 10.1080/15548627.2023.2235195
PMCID:
PMC10549198
AbstractArticlePDF–9.9M
4.
PIK3C3/VPS34 helps school T cells in the thymus
J. Luke Postoak, Wenqiang Song, Lan Wu, Luc Van Kaer
Autophagy. 2023; 19(6): 1890–1892. Published online 2022 Nov 23. doi: 10.1080/15548627.2022.2148428
PMCID:
PMC10262775
AbstractArticlePDF–658K
5.
Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases
Wenqiang Song, J. Luke Postoak, Guan Yang, Xingyi Guo, Heather H. Pua, Jackie Bader, Jeffrey C. Rathmell, Hanako Kobayashi, Volker H. Haase, Katrina L. Leaptrot, Alexandra C. Schrimpe-Rutledge, Stacy D. Sherrod, John A. McLean, Jianhua Zhang, Lan Wu, Luc Van Kaer
Proc Natl Acad Sci U S A. 2023 Jan 3; 120(1): e2214874120. Published online 2022 Dec 27. doi: 10.1073/pnas.2214874120
PMCID:
PMC9910429
AbstractArticlePDF–2.2M
6.
Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection
J. Luke Postoak, Wenqiang Song, Guan Yang, Xingyi Guo, Shiyun Xiao, Cherie E. Saffold, Jianhua Zhang, Sebastian Joyce, Nancy R. Manley, Lan Wu, Luc Van Kaer
J Exp Med. 2022 Oct 3; 219(10): e20212554. Published online 2022 Aug 23. doi: 10.1084/jem.20212554
PMCID:
PMC9402993
AbstractArticlePDF–6.9M
7.
Endosomal phosphatidylinositol 3‐phosphate controls synaptic vesicle cycling and neurotransmission
Guan‐Ting Liu, Gaga Kochlamazashvili, Dmytro Puchkov, Rainer Müller, Carsten Schultz, Albert I Mackintosh, Dennis Vollweiter, Volker Haucke, Tolga Soykan
EMBO J. 2022 May; 41(9): e109352. Published online 2022 Mar 22. doi: 10.15252/embj.2021109352
PMCID:
PMC9058544
AbstractArticlePDF–4.6M
8.
Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis
Guan Yang, J. Luke Postoak, Wenqiang Song, Jennifer Martinez, Jianhua Zhang, Lan Wu, Luc Van Kaer
Autophagy. 2022; 18(1): 161–170. Published online 2021 May 7. doi: 10.1080/15548627.2021.1922051
PMCID:
PMC8865280
AbstractArticlePDF–2.3M
9.
Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production
Guan Yang, Wenqiang Song, Jielin Xu, J. Luke Postoak, Feixiong Cheng, Jennifer Martinez, Jianhua Zhang, Lan Wu, Luc Van Kaer
Cell Mol Immunol. 2021 Aug; 18(8): 2024–2039. Published online 2020 Nov 24. doi: 10.1038/s41423-020-00589-1
PMCID:
PMC8322046
AbstractArticlePDF–6.7M
10.
Cre/loxP approach-mediated downregulation of Pik3c3 inhibits the hypertrophic growth of renal proximal tubule cells
Ting Liu, Jialing Yuan, Caihong Dai, Jinxian Xu, Shude Li, Benjamin D. Humphreys, Daniel T. Kleven, Jian-Kang Chen
J Cell Physiol. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: J Cell Physiol. 2020 Dec; 235(12): 9958–9973. Published online 2020 May 31. doi: 10.1002/jcp.29811
PMCID:
PMC8205307
AbstractArticlePDF–3.4M
11.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
12.
The expression level of class III phosphatidylinositol-3 kinase controls the degree of compensatory nephron hypertrophy
Ting Liu, Caihong Dai, Jinxian Xu, Shude Li, Jian-Kang Chen
Am J Physiol Renal Physiol. 2020 Mar 1; 318(3): F628–F638. Published online 2020 Jan 6. doi: 10.1152/ajprenal.00381.2019
PMCID:
PMC7099500
AbstractArticle
13.
LC3-associated endocytosis facilitates β-amyloid clearance and mitigates neurodegeneration in murine Alzheimer’s Disease
Bradlee L. Heckmann, Brett J.W. Teubner, Bart Tummers, Emilio Boada-Romero, Lacie Harris, Mao Yang, Clifford S. Guy, Stanislav S. Zakharenko, Douglas R. Green
Cell. Author manuscript; available in PMC 2020 Jul 25.
Published in final edited form as: Cell. 2019 Jul 25; 178(3): 536–551.e14. Published online 2019 Jun 27. doi: 10.1016/j.cell.2019.05.056
Correction in:
Cell. 2020 Dec 10; 183(6): 1733–1734.
PMCID:
PMC6689199
AbstractArticlePDF–3.5M
14.
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth
Xing Feng, Yanyan Jia, Yuyu Zhang, Fei Ma, Yuekun Zhu, Xuehui Hong, Qingxin Zhou, Ruixing He, Heng Zhang, Junfei Jin, Daxun Piao, He Huang, Qinghua Li, Xingfeng Qiu, Zhiyong Zhang
Autophagy. 2019; 15(7): 1130–1149. Published online 2019 Jan 27. doi: 10.1080/15548627.2019.1570063
PMCID:
PMC6613838
AbstractArticlePDF–10M
15.
Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells
Feng He, Ralph M. Nichols, Lavanya Kailasam, Theodore G. Wensel, Melina A. Agosto
Invest Ophthalmol Vis Sci. 2019 Jul; 60(8): 2861–2874. doi: 10.1167/iovs.19-26586
PMCID:
PMC6607926
AbstractArticlePDF–3.4M
16.
Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice
Ianina C. Ferder, Leslie Fung, Yasuyo Ohguchi, Xiaoyu Zhang, Kara G. Lassen, Diane Capen, Dennis Brown, Ramnik J. Xavier, Ning Wang
PLoS Genet. 2019 May; 15(5): e1008084. Published online 2019 May 6. doi: 10.1371/journal.pgen.1008084
PMCID:
PMC6502318
AbstractArticlePDF–7.5M
17.
LC3-associated phagocytosis in myeloid cells promotes tumor immune tolerance
Larissa Dias Cunha, Mao Yang, Robert Carter, Clifford Guy, Lacie Harris, Jeremy Chase Crawford, Giovanni Quarato, Emilio Boada-Romero, Halime Kalkavan, Michael David Leslie Johnson, Sivaraman Natarajan, Meghan Elizabeth Turnis, David Finkelstein, Joseph Thomas Opferman, Charles Gawad, Douglas Ross Green
Cell. Author manuscript; available in PMC 2019 Oct 4.
Published in final edited form as: Cell. 2018 Oct 4; 175(2): 429–441.e16. Published online 2018 Sep 20. doi: 10.1016/j.cell.2018.08.061
PMCID:
PMC6201245
AbstractArticlePDF–1.1M
18.
Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis
Harilaos Filippakis, Amine Belaid, Brian Siroky, Constance Wu, Nicola Alesi, Thomas Hougard, Julie Nijmeh, Hilaire C. Lam, Elizabeth P. Henske
Sci Rep. 2018; 8: 14161. Published online 2018 Sep 21. doi: 10.1038/s41598-018-32256-x
PMCID:
PMC6155086
AbstractArticlePDF–1.2M
19.
Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency
Giuseppina Grieco, Virginie Janssens, Héloïse P. Gaide Chevronnay, Francisca N’Kuli, Patrick Van Der Smissen, Tongsong Wang, Jingdong Shan, Seppo Vainio, Benoit Bilanges, François Jouret, Bart Vanhaesebroeck, Christophe E. Pierreux, Pierre J. Courtoy
Sci Rep. 2018; 8: 14133. Published online 2018 Sep 20. doi: 10.1038/s41598-018-32389-z
PMCID:
PMC6148293
AbstractArticlePDF–3.3M
20.
HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers
Bilon Khambu, Nazmul Huda, Xiaoyun Chen, Yong Li, Guoli Dai, Ulrike A. Köhler, Wei-Xing Zong, Satoshi Waguri, Sabine Werner, Tim D. Oury, Zheng Dong, Xiao-Ming Yin
J Clin Invest. 2018 Jun 1; 128(6): 2419–2435. Published online 2018 May 7. doi: 10.1172/JCI91814
Correction in:
J Clin Invest. 2019 May 1; 129(5): 2163.
Expression of Concern in:
J Clin Invest. 2019 May 1; 129(5): 2163.
PMCID:
PMC5983330
AbstractArticlePDF–28M

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